Faculty and Research Areas

student using a pipette in a laboratory surrounded by other lab equipment

Molecular and Biomedical Sciences

Faculty and Research Areas

The research conducted by �ϻ�� Molecular and Biomedical Sciences (MBS) faculty is diverse in scope. The following is a partial list of areas that you could pursue as a graduate student here at the �ϻ��. We encourage you to access the web pages of the faculty associated with the research areas listed below, and contact them directly to learn more about their programs of discovery. All of these faculty members are currently involved in graduate training, and many have openings for new students in their laboratories.

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Michael Minnick

Professor, CMMB

Contact

Office: Health Sciences 509
Phone: (406) 243-5972
Email: mike.minnick@mso.umt.edu
Office Hours: I have an open door policy- students may come by any time.
Curriculum Vitae

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Education

B.S. Biology- Walla Walla University, 1982
M.S. Biology- Walla Walla University, 1984
Ph.D. Microbiology- Washington State University, 1987

Courses Taught

· Pathogenic Microbes (BIOM 402)

· Pathogenic Microbes Laboratory (BIOM 403)

· General Microbiology (BIOM 360)

· General Microbiology Laboratory (BIOM 361)

· Microbial Pathogenesis (BIOM 540)

Teaching Experience

Washington State University-

· General Microbiology Laboratory (Micb 201)

Walla Walla University-

· General Biology (Biol 100)

The �ϻ��-

· Medical Bacteriology and Mycology (BIOM 402)

· Medical Bacteriology and Mycology Laboratory (BIOM 403)

· General Microbiology (BIOM 360)

· General Microbiology Laboratory (BIOM 361)

· Medical Microbiology (Micb 302)

· Advanced Molecular Biology Lab (Micb 499)

· Elementary Medical Microbiology (Micb 106)

· Microbial Pathogenesis (Micb 540)

· Immunology (Micb 410)

· Immunology Laboratory (Micb 411)

· Advanced Immunology (Micb 502; graduate course)

· Montana NIH BRIN Molecular Biology Workshops, 2002, 2003

Research Interests

Eleven validated Bartonella species are arthropod-borne, emerging infectious agents of human disease and are responsible for severe illnesses of the circulatory system (e.g., bacillary angiomatosis, hepatis peliosis, endocarditis, etc.). Roughly 40 additional Bartonella species infect a variety of other mammals including rodents, cats, dogs, livestock and wildlife. Our lab studies molecular and genetic aspects of Bartonella – human and Bartonella - arthropod vector interfaces, with special emphasis on elucidating mechanisms contributing to: a) parasitism of erythrocytes and vascular endothelial cells, b) iron acquisition, c) pathological angiogenesis during infection and d) persistence within the human host and arthropod vector. Our studies are expected to contribute towards eventual control strategies for these pathogens and vectors.

Our lab also works with Coxiella burnetii- one of the most infectious bacterial pathogens known. Research on Coxiella focuses on understanding its complex developmental cycle, unusual genetic elements (introns, ribozymes, inteins, small non-coding RNAs) and marked persistence in the environment. This research is designed to counter the potential bio-terrorist threat imposed by the illegitimate use of C. burnetii.

Field of Study

Microbial pathogenesis, molecular microbiology

Selected Publications

SELECTED RECENT PUBLICATIONS-

Quaiyum, S., Y. Yuan, G. Sun, R.M. Madhushi N. Ratnayake, G. Hutinet, P.C. Dedon, M.F. Minnick, and V de Crécy-Lagard. 2024. Queuosine salvage in Bartonella henselae Houston 1: a unique evolutionary path. Microbiology (Reading). Sep;170(9). doi: 10.1099/mic.0.001490. PMID: 39234940.

Minnick, M.F. Functional roles and genomic impact of miniature inverted-repeat transposable elements (MITEs) in prokaryotes. 2024. Genes. 2024, 15, 328.https://doi.org/10.3390/genes15030328

Quaiyum, S., G. Sun, J. Sun, Y. Yuan, C.J. Reed, V. Marchand, Y. Motorin, P.C. Dedon, M.F. Minnick, and V. de Crécy-Lagard. 2024. Mapping the tRNA Modification landscape of Bartonella henselae Houston I and Bartonella quintana Toulouse. Frontiers in Microbiology. 15:1369018. doi: 10.3389/fmicb.2024.1369018

Minnick, M.F. A.J. Robinson, R.D. Powell, and T.E. Rowland. 2023. Experimental colonization of sand flies (Lutzomyia longipalpis; Diptera: Pscychodidae) by Bartonella ancashensis. Vector Borne Zoonotic Dis. 2023 Mar 20. doi: 10.1089/vbz.2022.0087. Epub ahead of print. PMID: 36939868.

Andrew F.J., L.D. Hicks and M.F. Minnick. 2022. A system for transposon mutagenesis of Bartonella bacilliformis. J Microbiol Methods. Nov 16;203:106623. doi: 10.1016/j.mimet.2022.106623. PMID: 36400246

Wachter, S., L.D. Hicks, R. Raghavan and M.F. Minnick. 2020. Novel small RNAs expressed by Bartonella bacilliformis under multiple conditions reveal potential mechanisms for persistence in the sand fly vector and human host. PLOS Negl. Trop. Dis. 14(11): e0008671. https://doi.org/10.1371/journal.pntd.0008671.

Hicks, L.D., and M.F. Minnick. 2020. Human vascular endothelial cells express epithelial growth factor in response to infection by Bartonella bacilliformis. PLOS Negl. Trop. Dis. Apr 17;14(4):e0008236. PMID: 32302357

Banerjee, R., O. Shine, V. Rajachandran, K. Govind, M.F. Minnick, S. Paul, and S. Chattopadhyay. 2020. Gene duplication and deletion, not horizontal transfer, drove intra-species mosaicism of Bartonella henselae. Genomics Jan;112(1):467-471. doi: 10.1016/j.ygeno.2019. 03.009. Epub 2019 Mar 19. PMID: 30902757

Publications

For a complete list of published work (88 publications) see: https://www.ncbi.nlm.nih.gov/myncbi/michael.minnick.2/bibliography/public/

Peer-reviewed Articles-

76. Quaiyum, S., Y. Yuan, G. Sun, R.M. Madhushi N. Ratnayake, G. Hutinet, P.C. Dedon, M.F. Minnick, and V de Crécy-Lagard. 2024. Queuosine salvage in Bartonella henselae Houston 1: a unique evolutionary path. Microbiology (Reading). Sep;170(9). doi: 10.1099/mic.0.001490. PMID: 39234940.

75. Minnick, M.F. Functional roles and genomic impact of miniature inverted-repeat transposable elements (MITEs) in prokaryotes. 2024. Genes. 2024, 15, 328.https://doi.org/10.3390/genes15030328

74. Quaiyum, S., G. Sun, J. Sun, Y. Yuan, C.J. Reed, V. Marchand, Y. Motorin, P.C. Dedon, M.F. Minnick, and V. de Crécy-Lagard. 2024. Mapping the tRNA Modification landscape of Bartonella henselae Houston I and Bartonella quintana Toulouse. Frontiers in Microbiology. 15:1369018. doi: 10.3389/fmicb.2024.1369018. PMID: 38544857

73. Minnick, M.F. A.J. Robinson, R.D. Powell, and T.E. Rowland. 2023. Experimental colonization of sand flies (Lutzomyia longipalpis; Diptera: Pscychodidae) by Bartonella ancashensis. Vector Borne Zoonotic Dis. 2023 Mar 20. doi: 10.1089/vbz.2022.0087. Epub ahead of print. PMID: 36939868.

72. Andrew F.J., L.D. Hicks and M.F. Minnick. 2022. A system for transposon mutagenesis of Bartonella bacilliformis. J Microbiol Methods. Nov 16;203:106623. doi: 10.1016/j.mimet.2022.106623. PMID: 36400246.

71. Wachter, S., L.D. Hicks, R. Raghavan and M.F. Minnick. 2020. Novel small RNAs expressed by Bartonella bacilliformis under multiple conditions reveal potential mechanisms for persistence in the sand fly vector and human host. PLOS Negl. Trop. Dis. 14(11): e0008671. https://doi.org/10.1371/journal.pntd.0008671.

70. Hicks, L.D., and M.F. Minnick. 2020. Human vascular endothelial cells express epithelial growth factor in response to infection by Bartonella bacilliformis. PLOS Negl. Trop. Dis. Apr 17;14(4):e0008236. PMID: 32302357

69. Banerjee, R., O. Shine, V. Rajachandran, K. Govind, M.F. Minnick, S. Paul, and S. Chattopadhyay. 2020. Gene duplication and deletion, not horizontal transfer, drove intra-species mosaicism of Bartonella henselae. Genomics Jan;112(1):467-471. doi: 10.1016/j.ygeno.2019. 03.009. Epub 2019 Mar 19.

68. Wachter, W., M. Bonazzi, K. Shifflett, A.S. Moses, R. Raghavan, and M.F. Minnick. 2019. A CsrA-binding, trans-acting sRNA of Coxiella burnetii is necessary for optimal intracellular growth and vacuole formation during early infection of host cells. Journal of Bacteriology Oct 21;201(22). pii: e00524-19. doi: 10.1128/JB.00524-19. PMID: 31451541

67. Wachter, S, R. Raghavan, J. Wachter and M.F. Minnick. 2018. Identification of novel MITEs (miniature inverted-repeat transposable elements) in Coxiella burnetii: implications for protein and small RNA evolution. BMC Genomics 19:247.

66. Battisti, J.M., L.A. Watson, M.T. Naung, A.M. Drobish, E. Voronina and M.F. Minnick. 2017. Caenorhabditis elegans immune response to Coxiella burnetii. Innate Immunity. 23:111-127.

65. Warrier, I., M.C. Walter, D. Frangoulidis, R. Raghavan, L.D. Hicks and M.F. Minnick. 2016. The intervening sequence of Coxiella burnetii: characterization and evolution. Front. Cell. Infect. Microbiol. 6:83. doi:10.3389/fcimb.2016.00083.

64. Paul, S., M.F. Minnick, and S. Chattopadhyay. 2016. Mutation-driven divergence and convergence indicate adaptive evolution of the intracellular human-restricted pathogen, Bartonella bacilliformis. PLoS Negl. Trop. Dis. 10(5): e0004712. doi:10.1371/journal.pntd.0004712.

63. Battisti, J.M., P.G Lawyer and M.F. Minnick. 2015. Colonization of Lutzomia verrucarum and Lutzomyia longipalpis sand flies (Diptera: Psychodidae) by Bartonella bacilliformis, the etiologic agent of Carrión’s disease. PLoS Negl. Trop. Dis. 9(10): e0004128. DOI: 10.1371/journal. pntd.0004128. PMCID: 4593541

62. Henriquez-Camacho C., P. Ventosilla P, M.F. Minnick , J. Ruiz, C Maguiña. 2015. Proteins of Bartonella bacilliformis: candidates for vaccine development. Int. J. Peptides. Volume 2015, Article ID 702784, 5 pages .

61. Minnick, M.F., B.E. Anderson, A. Lima, J.M. Battisti, P.G. Lawyer, and R.J. Birtles. 2014. Oroya fever and verruga peruana- bartonelloses unique to South America. PLoS Negl. Trop. Dis. 8:e2919. PMCID: PMC4102455

60. Warrier, I., L.D. Hicks, J.M. Battisti, R. Raghavan, and M.F. Minnick. 2014. Identification of novel small RNAs and characterization of the 6S RNA of Coxiella burnetii. PLoS ONE 9:e100147. PMCID: PMC4064990

59. Parrow, N.L., R.E. Fleming, and M.F. Minnick. 2013. Sequestration and scavenging: iron in infection. Infect. Immun. 81:3503-3514. PMCID: PMC3811770

58. Wright, B.E., K.H. Schmidt, and M.F. Minnick. 2013. Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man. Mutat. Res. 752:129-137. PMCID: PMC3631585

57. Wright, B.E., K.H. Schmidt, A.T. Hunt, D.K. Reschke, and M.F. Minnick. 2011. Evolution of coordinated mutagenesis and somatic hypermutation in VH5. Mol. Immunol. 49:537-548. PMCID: PMC3235918

56. Minnick, M.F., and R. Raghavan. 2011. Invited author. Genetics of Coxiella burnetii: on the path of specialization. Future Microbiol. 6:1297-1314.

55. Wright, B.E., K. Schmidt, A.T. Hunt. J.S. Lodmell, M.F. Minnick, and D. Reschke. 2011. The roles of transcription and genotoxins underlying p53 mutagenesis in vivo. Carcinogenesis. 32:1559-1567. PMCID: PMC3179427

54. Hicks, L.D., I. Warrier, R. Raghavan, and M.F. Minnick. 2011. Ribozyme stability, exon skipping and potential role for RNA helicase in group I intron splicing by Coxiella burnetii. J. Bacteriol. 193:5292-5299. PMCID: PMC3187410

53. Battisti, J.M, L.D. Hicks, and M.F. Minnick. 2011. A unique Coxiella burnetii lipoprotein involved in metal-binding (LimB). Microbiology 157:966-976. PMCID: PMC3139440

52. Minnick, M.F., L.D. Hicks, J.M. Battisti, and R. Raghavan. 2010. Pentamidine inhibits Coxiella burnetii growth and 23S rRNA intron splicing in vitro. Int. J. Antimicrob. Agents 36:380-382. PMCID: PMC2926257

51. Hicks, L.D., R. Raghavan, J.M. Battisti, and M.F. Minnick. 2010. A DNA-binding peroxiredoxin of Coxiella burnetii is involved in countering oxidative stress during exponential-phase growth. J. Bacteriol. 192:2077-2084. PMCID: PMC2849434

50. Raghavan, R., and M.F. Minnick. 2009. Group I introns and inteins: disparate origins, but convergent parasitic strategies. J. Bacteriol. 191:6193-6202. PMCID: PMC2753036

49. Minnick, M.F., and J.M. Battisti. 2009. Invited author. Pestilence, persistence and pathogenicity: infection strategies of Bartonella. Future Microbiol. 4:743-758. PMCID: PMC2754412

48. Raghavan, R., L.D. Hicks, and M.F. Minnick. 2009. A unique group I intron in Coxiella burnetii is a natural splice mutant. J. Bacteriol. 191:4044-4046. PMCID: PMC2698393

47. Parrow, N.L., J. Abbott, A.R. Lockwood, J.M. Battisti, and M.F. Minnick. 2009. Function, regulation, and transcriptional organization of the hemin utilization locus of Bartonella quintana. Infect. Immun. 77:307-316. PMCID: PMC2612243

46. Raghavan, R., L.D. Hicks, and M.F. Minnick. 2008. Toxic introns and parasitic intein in Coxiella burnetii: legacies of a promiscuous past. J. Bacteriol. 190:5934-5943. PMCID: PMC2519523

45. Wright, B.E., K.H. Schmidt, N. Davis, A.T. Hunt, and M.F. Minnick. 2008. II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation. Molec. Immunol. 45:3600-3608. PMCID: PMC2529022

44. Wright, B.E., K.H. Schmidt, M.F. Minnick, and N. Davis. 2008. I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation. Molec. Immunol. 45:3589-3599. PMCID: PMC2570340

43. Raghavan, R., S.R. Miller, L.D. Hicks, and M.F. Minnick. 2007. The unusual 23S rRNA gene of Coxiella burnetii: two self-splicing group I introns flank a 34-base-pair exon and one element lacks the canonical omega G. J. Bacteriol. 189:6572-6579. PMCID: PMC2045182

42. Battisti, J.M. K.N. Sappington, L.S. Smitherman, N.L. Parrow, R. Raghavan, and M.F. Minnick. 2007. Transcriptional regulation of the heme binding protein gene family of Bartonella quintana is accomplished by a novel promoter element and iron response regulator (Irr) Infect. Immun. 75:4373-4385. PMCID: PMC1951173

41. Boonjakuakul, J.K., H.L. Gerns, Y.-T. Chen, L.D. Hicks, M.F. Minnick, S.E. Dixon, S.C. Hall, and J.E. Koehler. 2007. Proteomic and immunoblot analyses of Bartonella quintana total membrane proteins identify antigens recognized by sera from infected patients. Infect. Immun. 75:2548-2561. PMCID: PMC1865797

40. Battisti, J.M., K.N. Sappington, L.S. Smitherman, N.L. Parrow, and M.F. Minnick. 2006. Environmental signals generate a differential and coordinated expression of the heme receptor gene family of Bartonella quintana. Infect. Immun. 74:3251-3261. PMCID: PMC1479232

39. Smitherman, L.S., and M.F. Minnick. 2005. Bartonella bacilliformis GroEL: effect on growth of human vascular endothelial cells in infected co-cultures. Ann. NY Acad. Sci. 1063:286-298. PMCID: PMC1817666

38. Callison, J.A., J.M. Battisti, Kate N. Sappington, L.S. Smitherman, and M.F. Minnick. 2005. Characterization and expression analysis of the groESL operon of Bartonella bacilliformis. Gene 359:53-62. PMCID: PMC1885459

37. Wright, B.E., K.H. Schmidt, and M.F. Minnick. 2004. A mechanism by which transcription can regulate somatic hypermutation. Genes Immun. 5:176-182.

36. Minnick, M.F., L.S. Smitherman, and D.S. Samuels. 2003. Mitogenic effect of Bartonella bacilliformis on human vascular endothelial cells and involvement of GroEL. Infect. Immun. 71:6933-6942. PMCID: PMC308913

35. Coleman, S.A., and M.F. Minnick. 2003. Differential expression of the invasion-associated locus B (ialB) gene of Bartonella bacilliformis in response to environmental cues. Microb. Pathogen. 34:179-186.

34. Minnick, M.F., K.N. Sappington, L.S. Smitherman, S.G.E.Andersson, O. Karlberg, and J.A. Carroll. 2003. A five-member gene family of Bartonella quintana. Infect. Immun. 71:814-821. PMCID: PMC145397

33. Minnick, M.F., Z.R. Wilson, L.S. Smitherman, and D.S. Samuels. 2003. gyrA mutations in ciprofloxacin-resistant Bartonella bacilliformis strains obtained in vitro. Antimicrob. Agents Chemother. 47:383-386. PMCID: PMC148966

32. Coleman, S.A., and M.F. Minnick. 2001. Establishing a direct role for the invasion-associated locus B protein of Bartonella bacilliformis in erythrocyte parasitism. Infect. Immun. 69:4373-4381. PMCID: PMC98509

31. Fournier, P.E., M.F. Minnick, H. Lepidi, and D. Raoult. 2001. Experimental model of human body louse infection using green fluorescent protein-expressing Bartonella quintana. Infect. Immun. 69:1876-1879. PMCID: PMC98095

30. Carroll, J.A., S.A. Coleman, L.S. Smitherman, and M.F. Minnick. 2000. Hemin-binding surface protein from Bartonella quintana. Infect. Immun. 68:6750-6757. PMCID: PMC97776

29. Barbian, K.D., and M.F. Minnick. 2000. A bacteriophage-like particle from Bartonella bacilliformis. Microbiology 146:599-609.

28. Battisti, J.M., and M.F. Minnick. 1999. Development of a system for genetic manipulation of Bartonella bacilliformis. Appl. Environ. Microbiol. 65:3441-3448. PMCID: PMC91517

27. Cartwright, J.L, P. Britton, M.F. Minnick, and A.G. McLennan. 1999. The ialA invasion gene of Bartonella bacilliformis encodes a (di)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria. Biochem. Biophys. Res. Comm. 256:474-479.

26. Battisti, J.M, L.S. Smitherman, D.S. Samuels, and M.F. Minnick. 1998. Mutations in Bartonella bacilliformis gyrB confer resistance to coumermycin A₁. Antimicrob. Agents Chemother. 42:2906-2913. PMCID: PMC105964

25. Minnick, M.F., and K.D. Barbian. 1997. Identification of Bartonella using PCR; genus- and species-specific primer sets. J. Microbiol. Methods 31:51-57.

24. Mitchell, S.J., and M.F. Minnick. 1997. Cloning, functional expression, and complementation analysis of an inorganic pyrophosphatase from Bartonella bacilliformis. Can. J. Microbiol. 43:734-743.

23. Mitchell, S.J., and M.F. Minnick. 1997. A carboxy-terminal processing protease gene is located immediately upstream of the invasion-associated locus from Bartonella bacilliformis. Microbiology 143:1221-1233.

22. Wright, B.E., and M.F. Minnick. 1997. Reversion rates in a leuB auxotroph of Escherichia coli K12 correlate with ppGpp levels during exponential growth. Microbiology 143:847-854.

21. Minnick, M.F., S.J. Mitchell, and S.J. McAllister. 1996. Invited author. Cell entry and the pathogenesis of Bartonella infections. Trends Microbiol. 4:343-347.

20. Minnick, M.F., S.J. Mitchell, S.J. McAllister, and J. M. Battisti. 1995. Nucleotide sequence analysis of the 23S ribosomal RNA-encoding gene of Bartonella bacilliformis. Gene 162:75-79.

19. Mitchell, S.J., and M.F. Minnick. 1995. Characterization of a two-gene locus from Bartonella bacilliformis associated with the ability to invade human erythrocytes. Infect. Immun. 63:1552-1562.

18. Grasseschi, H.A., and M.F. Minnick. 1994. Transformation of Bartonella bacilliformis by electroporation. Can. J. Microbiol. 40:782-786.

17. Minnick, M.F., Strange, J.C., and K.F. Williams. 1994. Characterization of the 16S-23S rRNA intergenic spacer of Bartonella bacilliformis. Gene 143:149-150.

16. Minnick, M.F. 1994. Identification of outer membrane proteins of Bartonella bacilliformis. Infect. Immun. 62:2644-2648.

15. Scherer, D.C., I. DeBuron-Connors, and M.F. Minnick. 1993. Characterization of Bartonella bacilliformis flagella and effect of antiflagellin antibodies on invasion of human erythrocytes. Infect. Immun. 61:4962-4971.

14. Minnick, M.F., and G.L. Stiegler. 1993. Nucleotide sequence and comparison of the 5S ribosomal RNA genes of Rochalimaea henselae, R. quintana, and Brucella abortus. Nucleic Acids Res. 21:2518.

13. Minnick, M.F. 1993. Characterization of the fMet initiator tRNA gene of Bartonella bacilliformis. Gene 131:151-152.

12. Minnick, M.F. 1993. Nucleotide sequence of the 5S ribosomal RNA gene of Bartonella bacilliformis. Nucleic Acids Res. 21:1036.

11. Minnick, M.F., and D.C. Scherer. 1993. Cloning and sequence analysis of a hemolysin-encoding gene from Pseudomonas paucimobilis. Gene 130:57-63.

10. Spence, K.D., J.E. Karlinsey, T.R. Kyriakides, C.S. Patil, and M.F. Minnick. 1992. Regulation and synthesis of selected bacteria-induced proteins in Manduca sexta. Insect Biochem. Molec. Biol. 22:321-331.

9. Minnick, M. F., L. C. Stillwell, J. M. Heineman, and G. L. Stiegler. 1992. A highly repetitive DNA sequence possibly unique to canids. Gene 110:235-238.

8. Minnick, M. F., C. Small, M. E. Frazier, and L. P. Mallavia. 1991. Analysis of strain-specific plasmid sequences from Coxiella burnetii. Acta Virol. 35:497-502.

7. Minnick, M. F., R. A. Heinzen, D. K. Reschke, M. E. Frazier, and L. P. Mallavia. l991. A plasmid-encoded surface protein found in chronic isolates of Coxiella burnetii. Infect. Immun. 59:4735-4739.

6. Minnick, M. F., C. Small, M. E. Frazier, and L. P. Mallavia. 1991. Analysis of the cbhE' plasmid gene from acute disease-causing isolates of Coxiella burnetii. Gene 103:113-118.

5. Mallavia, L. P., L. L. Whiting, M.F. Minnick, R. A. Heinzen, D. Reschke, M. Foreman, O. G. Baca, and M. E. Frazier. 1990. Strategy for differentiation of Coxiella burnetii strains using polymerase chain reaction. Ann. New York Acad. Sci. 590:572-581.

4. Minnick, M.F., R. A. Heinzen, R. Douthardt, L. P. Mallavia, and M. E. Frazier. 1990. Analysis of QpRS-specific sequences from Coxiella burnetii. Ann. New York Acad. Sci. 590:514-522.

3. Minnick, M. F., R. A. Heinzen, M. E. Frazier, and L. P. Mallavia. l990. Characterization and expression of the cbbE'gene of Coxiella burnetii. J. Gen. Microbiol. 136:1099-1107.

2. Minnick, M.F., and K. D. Spence. l988. Tissue site and modification of a bacteria-induced coagulation protein from Manduca sexta. Insect Biochem. 18:637-644.

1. Minnick, M.F., R. A. Rupp, and K. D. Spence. l986. A bacterial-induced lectin which triggers hemocyte coagulation in Manduca sexta. Biochem. Biophys. Res. Comm. 137:729-735.

Book Chapters-

12. Marrie, T.J., M.F. Minnick, J. Textoris, C. Capo, and J.-L. Mege. 2014. Invited author. Coxiella. Chapter 106. In: Molecular Medical Microbiology 2^nd Edition. (Tang et al., eds.) Academic Press, London. Pages 1941-1972.

11. Minnick, M.F., and B.E. Anderson. 2014. Invited author. Bartonella. Chapter 105. In: Molecular Medical Microbiology 2^nd Edition. (Tang et al., eds.) Academic Press, London. Pages 1911-1939.

10. Minnick, M.F., and R. Raghavan. 2012. Invited author. Developmental biology of Coxiella burnetii. In: Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Agent (R. Toman, R.A. Heinzen, J.L. Mege, J.E. Samuel, eds.) Springer, Netherlands. 984:231-248.

9. Battisti, J.M., and M.F. Minnick. 2008. Invited author. Laboratory Maintenance of Bartonella quintana. In: Current Protocols in Microbiology. Unit 3C.1.1-3C.1.13. John Wiley & Sons, NJ.

8. Walker D. H., C. Maguiña, and M.F. Minnick. 2005. Invited author. Bartonelloses. Chapter 44. In: Tropical Infectious Diseases: Principles, Pathogens, and Practice, 2^nd Edition. (R.L. Guerrant, D.H. Walker, and P.F. Weller, eds.) Elsevier Press.

7. Minnick, M.F., and B. E. Anderson. 2001. Invited author. The Genus Bartonella. In: THE PROKARYOTES: an Evolving Electronic Resource for the Microbiological Community, 3rd Edition (latest update release 3.6) (M. Dworkin et al., eds.), Springer-Verlag, NY.

6. Minnick, M.F. 2001. Invited author. Bartonella. Chapter 99, pp.2115-2136. In: Molecular Medical Microbiology. (M. Sussman, ed.) Academic Press, London.

5. Minnick, M.F., and B. Anderson. 2000. Invited author. Bartonella interactions with host cells. pp. 97-123. In: Subcellular Biochemistry: Bacterial Invasion Into Eukaryotic Cells. Vol. 33. (J. Hacker and T. Oelschlaeger, eds.) Plenum Press, NY.

4. Fournier, P-E., M.F. Minnick, and D. Raoult. 1999. Transformation of Bartonella quintana to green fluorescent protein expression by electroporation. pp. 38-42. In: Rickettsia and Rickettsial Diseases at the Turn of the Third Millenium. (D. Raoult and P. Brouqui, eds.) Elsevier Press, Amsterdam.

3. Minnick, M.F. 1997. Invited author. Virulence determinants of Bartonella bacilliformis. pp. 197-211. In: Rickettsial Infections and Immunity. (B. Anderson, M. Bendinelli and H. Friedman, eds.) Plenum Press, NY.

2. Mallavia, L.P., and M.F. Minnick. 1995. Invited author. Coxiella burnetii as an etiologic agent. pp. 70-84. In: Q Fever in Humans and Animals. (Z. Anusz, ed.) Skrypty Akademii Rolniczo Press, Olsztyn, Poland.

1. Spence, K.D., and M.F. Minnick. 1992. Invited author. Bacterial challenge and significance of an inducible protein (M13) in coagulation and cell agglutination in Manduca sexta (Lepidoptera). pp. 273-287. In: Immunology of Insects and Other Arthropods. (A.P. Gupta, ed.) CRC Press, Boca Raton, FL.

Affiliations

American Society for Microbiology

American Society for Rickettsiology (past president)

Professional Experience

9/19-5/21 Program Director, CMMB Program, �ϻ��, Missoula, MT

9/01-present Professor, Division of Biological Sciences, �ϻ��, Missoula, MT

9/00-9/06 Director, Murdock Molecular Biology Facility, �ϻ��, Missoula, MT

1/03-7/06, Assistant Dean, Division of Biological Sciences, �ϻ��, Missoula

7/08-6/10 Assistant Dean, Division of Biological Sciences, �ϻ��, Missoula

1/98-9/00 Associate Director, Murdock Molecular Biology Facility, �ϻ��, Missoula, MT

8/96-8/01 Associate Professor, Division of Biological Sciences, �ϻ��, Missoula, MT

8/91- 8/96 Assistant Professor, Division of Biological Sciences, �ϻ��, Missoula, MT

6/90 - 7/91 Postdoctoral Fellow, Department of Molecular Biology, Battelle Pacific Northwest Laboratories, Richland, WA, with Dr. Marvin E. Frazier

l0/87 - 6/90 Postdoctoral Research Associate, Department of Microbiology, Washington State University, Pullman, WA, with Dr. Louis P. Mallavia

8/88 - 5/89 Instructor, Department of Microbiology, Washington State University, Pullman, WA

8/85 - 5/87 Graduate Teaching Assistant, Department of Microbiology, Washington State University, Pullman, WA

8/84 - 5/85 Graduate Research Assistant, Department of Microbiology, Washington State University, Pullman, WA

3/84 - 6/84 Instructor, Dept. of Biology, Walla Walla University, College Place, WA

l982 - l984 Graduate Teaching Assistant, Department of Biology, Walla Walla University, College Place, WA

l98l - l982 Undergraduate Teaching Assistant, Department of Biology, Walla Walla University, College Place, WA

International Experience

Past consultant to Peruvian National Institutes of Health for development of a vaccine against Carrion's disease.

Honors / Awards

Selected as Honorary Member, American Society for Rickettsiology, 2023-present

Editorial Board, PLOS ONE, 2020-present

Editorial Board, Fine Focus, 2013-present

Editorial Board, Frontiers in Cellular and Infection Microbiology, 2010-present

Editorial Board, Journal of Microbiological Methods, 2007-present

Outstanding Faculty Advising Award for undergraduate student advising, �ϻ��, 2012

Student Affairs, Faculty Recognition Award, �ϻ��, 2012

Honorary Member, Golden Key International Honour Society, 2011-present

Publication selected for Faculty of 1000 Biology, 2007 (Battisti et al., 2007)

Student Affairs Faculty Recognition Award, �ϻ��, 2007

10 Faculty Merit Awards from �ϻ�� (1994, 1995, 1998, 2000, 2003, 2004, 2008, 2010, 2012, 2017)

Outstanding Faculty Recognition Award, �ϻ�� Greek Life, 2003

Tenure, �ϻ��, 1997

Winston and Helen Cox Teaching Award, �ϻ��, 1995

Department of Energy (NORCUS) Postdoctoral Fellowship, 1990-1991

Washington State University Competitive Summer Research Assistantship, 1987

Victor Burke Memorial Fellowship, Washington State University, l985, l986

Dean's Award for Academic Excellence, Walla Walla University, l984

Graduation Cum Laude, Walla Walla University, l982

Outstanding Biology Graduate, Walla Walla University, l982

Hobbies

Fly fishing

Fly tying

Fly rod building

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Molecular and Biomedical Sciences